Ole Miss vs Florida Odds and Prediction: Week 4 SEC Showdown

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Ole Miss just knocked off Lane Kiffin. Now the Rebels have to do it on the road, against a ranked team that’s somehow still favored to win: a three-point favorite at home.

No. 4 Ole Miss travels to No. 21 Florida this Saturday in a game that will say a lot about both programs — one trying to prove its LSU win was real, the other trying to prove it belongs in the ranked conversation at all.

Ole Miss vs Florida Odds and Prediction: The Spread, Total and Moneyline

Here’s how DraftKings has this one set up:

• Spread: Ole Miss +3.5 (-115) / Florida -3.5 (-105)
• Moneyline: Ole Miss +136 / Florida -162
• Total: 60.5 (Over -115 / Under -105)

Florida being favored over a top-five team is the headline number here, and it’s largely a home-field call — the Gators have been tough to beat at The Swamp under new head coach Jon Sumrall.

Odds shift constantly. Check DraftKings for live numbers before betting.

How to Watch Ole Miss vs Florida

• Date: Saturday, Sept. 26
• Kickoff: 3:30 p.m. ET
• Location: Ben Hill Griffin Stadium, Gainesville
• TV: ABC
• Records: Both teams enter 3-0

Ole Miss vs Florida Odds and Prediction: Player to Watch

Trinidad Chambliss, QB, Ole Miss

Chambliss is the reason Ole Miss is a national title contender right now. Against LSU, he threw for 363 yards and two touchdowns and added another score on the ground — the kind of performance that’s turned him into the early Heisman front-runner.

Zoom out and the numbers get louder: since last season, Chambliss has thrown 29 touchdowns against just five interceptions, completing just under 67% of his passes. A road win over a ranked Florida team wouldn’t just help Ole Miss’s playoff resume — it would cement Chambliss as the guy to beat for the Heisman all year.

On the other side, Florida’s offense hasn’t found real rhythm yet. Quarterback Aaron Philo and the Gators rank 55th nationally in offensive EPA per play and sit 120th in EPA on passing plays specifically — numbers that will get tested against a defense that’s faced two ranked opponents already.

Ole Miss vs Florida Odds and Prediction: Final Pick

Florida’s 3-0 start looks better on paper than it does under the hood. The Gators needed a five-point escape against Auburn, and their other two wins came against FAU and Campbell — not exactly a murderer’s row. Philo has already thrown two interceptions this season, and this is by far the best defense he’s faced.

Ole Miss, meanwhile, has already beaten a top-10 LSU team and a ranked Louisville squad. The Rebels rank in the top 10 nationally in offensive EPA per play and inside the top 20 in offensive success rate — while their defense, ranked 54th in success rate but 23rd in EPA per play, has been better than the raw numbers suggest.

Home underdogs get disrespected. Road favorites getting only 3.5 points against a team playing this well? That’s the number to attack.

Pick: Ole Miss +3.5

FAQ: Ole Miss vs Florida Week 4

What are the odds for Ole Miss vs Florida?
Florida is a 3.5-point favorite at home, with Ole Miss getting +136 on the moneyline.

What time is the Ole Miss vs Florida game?
Kickoff is 3:30 p.m. ET on Saturday, Sept. 26, airing on ABC.

Who is favored in Ole Miss vs Florida?
Florida, despite being ranked lower than Ole Miss, is favored by 3.5 points due to home-field advantage.

Is Trinidad Chambliss playing this week?
Yes — Chambliss enters the game as the Heisman front-runner after a 363-yard, two-touchdown performance against LSU.

Where is Ole Miss vs Florida being played?
Ben Hill Griffin Stadium in Gainesville, Florida.